Published Date: Tuesday, October 30, 2018

Merck Canada Inc., distributor of SINEMET® (levodopa and carbidopa) in Canada, has released a statement noting that there are global manufacturing delays in the production and resupply of these products. The limited supply, which may result in back orders, is expected to continue into 2019. 

As of October 15th, and as indicated in the below table, the following products are subject to delays in resupply: 

Product Name

Anticipated Out of Stock

Anticipated Resupply

SINEMET® 100 mg/25 mg

November 16, 2018 (anticipated)


SINEMET® 250 mg/25 mg

October 15, 2018 (actual)

January 31, 2019

SINEMET® CR 100 mg/25 mg

June 28, 2018 (actual)

January 21, 2019

SINEMET® CR 200 mg/50 mg

February 28, 2019 (anticipated)



Some pharmacies have begun replacing SINEMET® with generics that are available in Canada. If you are switching to a generic, we caution that you may experience side effects. It is recommended that you speak with your neurologist and a pharmacist about any changes to your medication.

The most up-to-date information regarding SINEMET® supply details is available on


Last updated: January 7, 2019



View All News